I've never played the game the above video makes fun of, but anybody who has ever played a first person shooter (FPS) will understand the frustration of the clip's player/narrator. They do a good job of nailing pretty much everything that makes escort missions so painful.
For those not familiar with FPS, escort mission involve you having to walk from point A to point B with a computer generated character and prevent them from being killed. The mission is complicated by the fact that the character you escort will be a complete dunce.
Regardless, as irritating as Natalya is in the above video, she's still not a tenth as obnoxious as Sticky, a.k.a. The Annoying Man, from Fallout 3.